diff --git a/configure.ac b/configure.ac
index 088128e5e74..235acfe9181 100644
--- a/configure.ac
+++ b/configure.ac
@@ -4921,9 +4921,6 @@ if test "x$target_mach" = "xyes"; then
           CPPFLAGS_FOR_LIBGC="$CPPFLAGS_FOR_LIBGC -DTARGET_OSX"
           CFLAGS_FOR_LIBGC="$CFLAGS_FOR_LIBGC -DTARGET_OSX"
           target_osx=yes
-          if test "x$TARGET" = "xARM64"; then
-             BTLS_SUPPORTED=no
-          fi
        ], [
           AC_DEFINE(TARGET_IOS,1,[The JIT/AOT targets iOS])
           CPPFLAGS_FOR_LIBGC="$CPPFLAGS_FOR_LIBGC -DTARGET_IOS"
@@ -5942,7 +5939,11 @@ if test "x$enable_btls" = "xyes"; then
 		;;
 	aarch64)
 		btls_arch=aarch64
-		btls_cflags="-march=armv8-a+crypto"
+		if test "x$target_mach" = "xyes"; then
+			btls_cflags="-arch arm64"
+		else
+			btls_cflags="-march=armv8-a+crypto"
+		fi
 		;;
 	s390x)
 		btls_arch=s390x
diff --git a/mono/btls/CMakeLists.txt b/mono/btls/CMakeLists.txt
index 992f41e4c7f..ee3e956c5b0 100644
--- a/mono/btls/CMakeLists.txt
+++ b/mono/btls/CMakeLists.txt
@@ -21,6 +21,15 @@ if (MSVC OR CYGWIN)
 	set(BTLS_HOST_WIN32 1)
 endif ()
 
+if (NOT "${BTLS_ARCH}" STREQUAL "")
+	message (STATUS "SET ARCH: ${BTLS_ARCH}")
+	set (CMAKE_SYSTEM_PROCESSOR "${BTLS_ARCH}")
+endif ()
+
+if ((("${CMAKE_SYSTEM_PROCESSOR}" STREQUAL "arm64") OR ("${CMAKE_SYSTEM_PROCESSOR}" STREQUAL "aarch64")) AND APPLE AND NOT IOS)
+	set(OPENSSL_NO_ASM 1)
+endif ()
+
 if (NOT OPENSSL_NO_ASM)
 	if (BTLS_HOST_WIN32)
 		if (CYGWIN AND "${BTLS_ARCH}" STREQUAL "i386")
@@ -38,11 +47,6 @@ if (NOT OPENSSL_NO_ASM)
 	endif ()
 endif ()
 
-if (NOT "${BTLS_ARCH}" STREQUAL "")
-	message (STATUS "SET ARCH: ${BTLS_ARCH}")
-	set (CMAKE_SYSTEM_PROCESSOR "${BTLS_ARCH}")
-endif ()
-
 if (NOT MSVC)
 	if(${CMAKE_SYSTEM_NAME} MATCHES "AIX" OR ${CMAKE_SYSTEM_NAME} MATCHES "OS400")
 		# GCC+XCOFF doesn't support -fvisibility=hidden, and we would prefer XCOFF debugging info.